EBECEF INJECTION

COMPOSITION:Each vial contains:

• Ceftriaxone Sodium USP equivalent to Ceftriaxone (anhydrous) … 1g
• Lidocaine Injection BP 1% 5 ml as diluent
• Sterile Water for Injections BP 10 ml

PHARMACOLOGY

Ceftriaxone is a broad spectrum third generation cephalosporin with a long plasma elimination half life of approximately 8 hours in normal adults.

INDICATIONS

• Lower respiratory tract infection.
• Urinary tract infections.
• Pelvic inflammatory disease
• Bone and Joint infections.
• Intra Abdominal infections
• Prophylaxis: the use of a single preoperative dose may reduce the incidence of postoperative infections in patients undergoing surgical procedures classified as contaminated (e.g. Vaginal or abdominal hysterectomy) and in surgical patients for whom infection at the operative site would present serious risk (e.g. Coronary artery bypass surgery). Ceftriaxone is as effective as cefazolin in preventing infection following coronary artery bypass surgery.

CONTRA-INDICATIONS

Solutions in lignocaine should be administered intravenously. Ceftriaxone should not be given to patients with a history of hypersensitivity to cephalosporin antibiotics. Ceftriaxone should not be given to neonates with jaundice or those who are hypoalbuminemic or acidotic or have other conditions, such as prematurity, in which bilirubin binding is likely to be impaired.

ADVERSE EFFECTS

Ceftriaxone has been generally well tolerated. Adverse reactions are usually mild and transient. The most common side effects are gastrointestinal, consisting mainly of loose stools and diarrhea, nausea, vomiting, and cutanous reactions,

DOSAGE & APPLICATIONS

Administer IV or IM. Continue for at least 2 days after signs and symptoms of infection have disappeared. Usual duration is 4 to 14 days; in complicated infections, longer therapy may be required. For S.pyogenes, continue for at least 10 days.

STORAGE OR HANDLING RECOMMENDATION

• Store below 30°C in a cool dry place.
• Keep the medicine out of reach of children.
• Do not use the medicine after the expiry date.

Reconstitution Of Ceftriaxone With Sterile Water For Injections BP

	Vial/Bottle dosage Size	Amount of diluent to add (ml)	Resultant Concentration (mg/ml)
IV1	1g	9.6	100

Reconstitution of Ceftriaxone with Lidocaine with Lidocaine Injection BP 1% 5 ml

	Vial/Bottle dosage Size	Amount of diluent to add (ml)	Resultant Concentration (mg/ml)
IM1	1g	5.0	200

PRESENTATION

• Ebecef is available in 1000 mg