Antimalarial Products

IBAKWIK

Artemisinin 62.5 mg + Piperaquine Phosphate 375 mg

COMPOSITION: Each capsule contains:

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Artemisinin — 62.5 mg
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Piperaquine Phosphate — 375 mg
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Excipients 			q.s.
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PHARMACOLOGY

Artemisinin is a fast-acting antimalarial that rapidly reduces Plasmodium parasite biomass by generating free radicals within the parasite, leading to protein and membrane damage.
Piperaquine phosphate is a long-acting bisquinoline antimalarial that inhibits heme detoxification in the parasite’s food vacuole, resulting in toxic heme accumulation and parasite death.
The combination provides rapid parasite clearance (artemisinin) with sustained post-treatment prophylaxis (piperaquine), reducing recrudescence and resistance development.

INDICATIONS

IBAKWIK is a fixed-dose combination antimalarial drug used for the treatment of uncomplicated malaria caused by Plasmodium falciparum and other susceptible Plasmodium species.
Contraindications
● Known hypersensitivity to artemisinin, piperaquine, or any excipients
● Severe or complicated malaria
● Patients with known QT interval prolongation or significant cardiac conduction disorders
● Concomitant use with other QT-prolonging medications

INDICATIONS

● Use with caution in patients with cardiac disease or electrolyte imbalance
● Not recommended for use in the first trimester of pregnancy unless clearly indicated
● Caution in patients with hepatic impairment
● Do not exceed the recommended dose
● Ensure completion of the full treatment course to prevent treatment failure

Adverse Effect

Generally well tolerated. Possible adverse effects include:
● Gastrointestinal disturbances (nausea, vomiting, abdominal pain)
● Headache, dizziness
● Fatigue
● Palpitations (rare)
● Transient elevation of liver enzymes
If severe or persistent adverse reactions occur, discontinue use and seek medical advice.

SPECIAL PRECAUTION

It must not be used in first Trimester of Pregnancy

DOSAGE AND ADMINISTRATION

Oral administration. Capsules should be swallowed whole with water. Dosage and Administration

Capsules should be taken orally with water. Complete the full course of treatment as prescribed.

STORAGE OR HANDLING RECOMMENDATION

● Store below 30°C ● Protect from light and moisture ● Keep out of reach of children ● Do not use after the expiry date

PRESENTATION

IBAKWIK is supplied as capsules in blister packs, packed in cartons with an enclosed patient information leaflet.
Use only on the advice of a qualified healthcare professional.