SKINEO Cream

COMPOSITION:
● Ketoconazole BP — 10 mg
● Clobetasol Propionate BP — 0.25 mg
●Neomycin Sulfate USP — 5000 IU
●Cream base — q.s.
●Excipients — q.s.

PHARMACOLOGY

Ketoconazole is a broad-spectrum imidazole antifungal that inhibits ergosterol synthesis, disrupting fungal cell membrane integrity and leading to fungal cell death.
Clobetasol propionate is a highly potent topical corticosteroid that exerts strong anti-inflammatory, antipruritic, and vasoconstrictive effects, rapidly relieving erythema, swelling, and itching.
Neomycin sulfate is an aminoglycoside antibiotic that inhibits bacterial protein synthesis, providing coverage against susceptible Gram-positive and Gram-negative organisms.
This triple-action combination provides antifungal, antibacterial, and anti-inflammatory activity, making it suitable for severe inflammatory dermatoses with mixed infections.

INDICATIONS

SKINEO Cream is indicated for the topical treatment of steroid-responsive inflammatory skin conditions complicated by fungal and/or bacterial infection, including:

● Infected dermatitis and eczema
● Tinea infections with secondary bacterial infection
● Candidal skin infections with inflammation
● Other mixed dermatoses where antifungal, antibacterial, and anti-inflammatory therapy is required

CONTRA-INDICATIONS

● Hypersensitivity to clobetasol, ketoconazole, neomycin, or any component of the formulation
● Viral skin infections (e.g. herpes simplex, chickenpox)
● Tuberculous or syphilitic skin lesions
● Acne vulgaris, rosacea, or perioral dermatitis
● Use on the eyes or mucous membranes

Precautions

● For external use only
● Clobetasol is a potent corticosteroid; avoid prolonged use
● Use with caution on the face, groin, axillae, or under occlusive dressings
● Discontinue if irritation, sensitization, or worsening of symptoms occurs
● Avoid application on large areas of broken or ulcerated skin

Adverse Effects

Possible adverse effects include: ● Local burning, stinging, or irritation
● Skin thinning, striae, or hypopigmentation with prolonged use

DOSAGE & APPLICATIONS

Apply a thin layer of SKINEO Cream to the affected area once or twice daily, or as directed by a healthcare professional.
Rub gently until absorbed. Treatment duration should be limited to the shortest effective period.

STORAGE/HANDLING RECOMMENDATIONS

• Do not store above 30°C.
• Protect from excessive heat and light
• Keep the tube tightly closed after use
• Keep out of reach of children

PRESENTATION

• SKINEO Cream is supplied in tubes, packed in cartons with an enclosed patient information leaflet.
• Use only under medical supervision.